The 49ers could face Drew Lock when the Seahawks enter Levi's Stadium on Sunday.
Seattle called practice quarterback Sean Mannion to the main roster on Saturday because Geno Smith suffered a groin injury during the week that could keep him out of the deciding NFC West game.
If Smith is unable to play, Mannion, 31, would serve as Drew Lock's backup. Lock, a former top second-round pick by Denver in 2019, hasn't started a game in 2023 but has made two appearances. In those games, Lock completed four of 12 passes for 66 yards, with no touchdowns and one pick.
In San Francisco's 31-13 road win over Seattle on Thanksgiving, Smith completed 18 of 27 passes for 180 yards, no touchdowns and one interception. He was sacked six times, resulting in a loss of 48 yards.
Smith's apparent injury comes at a costly time for Seattle, as it desperately needs a win to stay in the division race rather than fall to 6-7. The Seahawks are also without linebacker Frank Clark (personal), while linebacker Jordyn Brooks (ankle), defensive tackle Jarran Reed (hamstring) and running backs Kenneth Walker III (oblique) and Zach Charbonnet (knee) are questionable.
In addition to Mannion, Seattle also designated linebacker Patrick O'Connell, presumably for depth in the Clark and Brooks situations.
But San Francisco will also have to do without some key players. Defensive end Arik Armstead (foot, knee), tight end Ross Dwelley (ankle) and wideout/returner Ray-Ray McCloud (rib) were all ruled out.
Guard Spencer Buford (knee), running back Elijah Mitchell (knee) and cornerback Darrell Luter Jr. (hamstring) are all questionable.
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