By reprogramming the cells of the immune system, obesity is one of the most important non-genetic risk factors for developing age-related macular degeneration (AMD) immediately after smoking.
That’s according to a study published in the journal Science, which found that life stressors disrupt the DNA architecture of inflammatory cells, making them destructive to the eye during aging. By examining the genes responsible for AMD, the scientists found that variations and mutations only increased, but did not cause, the risk of developing the disease. This assumption led researchers to consider other factors, such as environment and lifestyle, should be considered. Normally, immune cells keep the eye healthy, but are activated after encounters with pathogens such as bacteria and viruses. This study showed that immune cells are also activated when the body is exposed to stressors such as excess fat in obesity. AMD is a leading cause of irreversible blindness worldwide, affecting approximately 196 million people in 2020. This project was led by Dr. Przemyslaw (Mike) Sapieha and supervised by his postdoc Dr. Masayuki Hata from the Maisonneuve-Rosemont Hospital Research Center and the University of Montreal.
NEW DELHI, Jan 10 (Portal) – The growth of Google’s Android ecosystem is on the verge of a standstill in India due to an antitrust order requiring the company to change the way it markets the platform , the US company said in a challenge to the Supreme Court seen by Portal.
The Competition Commission of India (CCI) fined Alphabet Inc.-owned Google (GOOGL.O) US$161 million in October for abusing its dominant position in Android, which makes 97% of smartphones operates in India and called on it to change the restrictions placed on smartphone manufacturers related to pre-installation of apps.
Google has previously said the CCI ruling will force it to change its long-standing business model, but its filing with India’s Supreme Court quantifies the impact for the first time and outlines the changes the company needs to make.
Google must amend its existing contracts, introduce new licensing agreements, and amend its existing agreements with more than 1,100 device makers and thousands of app developers, it said.
“The tremendous growth progress of an ecosystem of device manufacturers, app developers and users is on the verge of a standstill due to the remedial measures,” says Google’s non-public filing.
“Google needs to make sweeping changes to the Android mobile platform, which has been around for 14-15 years.”
A Google spokesman declined to comment.
Google was concerned about the Indian decision as the remedies ordered are seen as more far-reaching than the European Commission’s landmark 2018 ruling imposing unlawful restrictions on Android mobile device makers. Google has appealed the record $4.3 billion fine in that case.
Google licenses its Android system to smartphone makers, but critics say it imposes restrictions like mandatory pre-installation of its own apps, which are anti-competitive. The company argues that such agreements help keep Android free.
The CCI ordered Google in October not to ban the uninstallation of its apps by Android phone users in India – currently one cannot delete apps like Google Maps or YouTube from their Android phones if they are pre-installed.
The CCI also said that Google’s licensing for its Play Store “should not be linked to the requirement of pre-installation” of Google search services, the Chrome browser, YouTube or other Google applications.
“No other jurisdiction has ever required such sweeping changes based on similar behavior,” Google said in its court filings.
The company has asked the Supreme Court to stay remedial measures ordered by the Chamber of Industry and Commerce, which take effect from Jan. 19, court documents dated Jan. 7 showed. The case is expected to be heard in the coming days.
Google has also claimed in its legal filing that the investigative unit of the CCI copied parts of a 2018 European judgment against the US firm, Portal reported. The IHK and the European Commission have not responded to these allegations.
Reporting by Aditya Kalra, Arpan Chaturvedi and Munsif Vengattil in New Delhi; Editing by Susan Fenton
A powerful new small satellite launch vehicle failed to earn wings on its first attempt.
ABL Space Systems’ RS1 rocket launched on its first-ever orbital mission on Tuesday (January 10), rising at 18:27 EST (2327 GMT; 14:27 local time in) from a pad at the Pacific Spaceport Complex on Alaska’s Kodiak Island on Alaska).
The two-stage rocket failed on the first flight because it could not launch a pair of CubeSats into low Earth orbit (LEO) as planned, ABL officials said. (The launch was not broadcast live.)
“After takeoff, RS1 experienced an anomaly and shut down prematurely. The team is working through our anomaly response procedures in coordination with the PSCA and the FAA.” ABL announced this via Twitter (opens in new tab) 23 minutes after launch. (The acronyms refer to the Pacific Spaceport Complex-Alaska and the US Federal Aviation Administration.)
At around midnight EST on Tuesday, ABL provided additional information via Twitter. All nine of the RS1’s first stage engines were shut down simultaneously and the rocket landed back on the launch pad and was destroyed. explained the company (opens in new tab).
“As expected in this scenario, there is damage to the launch facility. All employees are safe and the fires have subsided. We will plan our return to flight after the investigation is complete. Thank you to our stakeholders and the space community for the expressions of support,” ABL said in another tweet (opens in new tab).
Tuesday was the second day in a row with a starting anomaly. On Monday (January 9), Virgin Orbit’s LauncherOne rocket failed to reach orbit during the company’s first-ever launch from the UK, resulting in the loss of nine satellites.
Related: A History of Rockets
A growing field
Small satellites have two routes into orbit: they can be hitchhiked as “rideshare” payloads on large rockets like SpaceX’s Falcon 9, or they can get special rides in smaller vehicles that take them exactly where they want to go.
For the past several years, Rocket Lab has dominated the dedicated ride market with its Electron vehicle, which has more than 30 orbital missions under its belt. But other companies are also trying to carve out their own place in this area. Virgin Orbit, for example, had completed four consecutive spaceflights with flying colors before Monday’s failure, and Firefly Aerospace reached orbit for the first time with its Alpha vehicle in October 2022.
(Another company, Astra, successfully deployed payloads for the first time with its Rocket 3 in March 2022, but the company retired that vehicle after several failures and is now working on a larger rocket.)
The California-based ABL, founded in 2017, also wants to become a big player in the launch of small satellites with the RS1 and the associated ground system, which the company calls GSO.
The 27 meter high RS1 is equipped with nine E2 engines from ABL in the first stage and one E2 in the second. The consumable rocket can launch up to 2,975 pounds (1,350 kilograms) of payload to LEO, according to the ABL User Guide (opens in new tab).
The company is currently charging $12 million per RS1 launch — a relatively low price for this kind of launch power. For comparison, Rocket Lab is charging about $7.5 million for an electron mission capable of delivering about 300 kg (660 pounds) to LEO.
ABL emphasizes a commitment to vertical integration and simplicity of design as key to the desired success. In addition, both the RS1 and the GSO are easy to transport and deploy. The floor system, for example, fits into standard shipping containers and can be placed anywhere in the world where there is a flat base.
“With RS1 and GSO we are able to take launch where it is needed,” says ABL’s website (opens in new tab).
ABL – which has yet to reveal what that acronym stands for – already has significant customer buy-in to its vision. In 2021, for example, the company signed a deal with aerospace giant Lockheed Martin (opens in new tab) for up to 58 missions through 2029.
Success on Tuesday’s first mission would have been a big step toward such ambitious goals. However, the failure should not prove to be a major obstacle for ABL in the long term; after all, the first flights of rockets often do not go according to plan.
The Lost CubeSats
Although Tuesday’s mission was a test flight, the RS1 carried a ready-to-go spacecraft — shoebox-sized cubesat called the VariSat 1A and VariSat 1B, according to EverydayAstronaut.com (opens in new tab).
The CubeSats, each weighing approximately 11 kg, would have completed a three-satellite network operated by VariSat LLC. VariSat 1C is safely in orbit; It was launched on a Falcon 9 in May 2022 along with nearly five dozen other satellites.
The main objective of the VariSat 1 mission is “to experiment and gain flight experience with a satellite designed to support HF [high frequency] Marine Data Communications,” according to a filing (opens in new tab) with the US Federal Communications Commission.
ABL initially attempted to launch its debut mission in mid-November, but was unable to due to multiple aborts during the week-long window. The company then dropped an attempt on December 8, the second day of the next launch window, after noticing abnormal data from the RS1. ABL held off until January 9 to address this issue, then delayed launch another day due to weather.
Editor’s note: This news item was updated at 12:30 p.m. ET on January 11 with more details about the anomaly provided by ABL Space Systems.
Mike Wall is the author of Out There (opens in new tab) (Grand Central Publishing, 2018; illustrated by Karl Tate), a book on the search for extraterrestrial life. Follow him on Twitter @michaelwall (opens in new tab). Follow us on Twitter @spacedotcom (opens in new tab) or on Facebook (opens in new tab).
Strategic Wealth Partners investment strategist Luke Lloyd addresses the top risks for the economy in 2023, which could include a mild recession and a credit crunch.
Concerns about an “economic recession” grew Tuesday after Goldman Sachs began laying off employees as part of a plan to cut 3,200 jobs to cut costs.
Goldman Sachs is just the latest company to reduce its size in recent months. Morgan Stanley announced it would cut 2 percent of its workforce in December, Amazon plans to cut over 18,000 jobs, and Salesforce last week announced it would cut 10 percent of its workforce and close some offices.
While white-collar workers have been less affected by the lockdowns caused by the COVID-19 pandemic than their blue-collar counterparts, with many jobs simply being done remotely rather than being cut, working professionals are now bearing the brunt of the economic headwinds America is facing .
Goldman’s layoffs are one of the largest since the 2008 financial crisis.
US BANKS PREPARE FOR SHRINKING PROFIT AND RECESSION
Goldman Sachs Group Inc. Chief Executive Officer David Solomon during a Bloomberg Television at the Goldman Sachs Financial Services Conference in New York, U.S. on Tuesday, December 6, 2022. Solomon predicts “rough times” for the global economy , m (Photographer: Michael Nagle/Bloomberg via Getty Images/Getty Images)
“Today alone, 26,000 more layoffs were announced… from Amazon and Salesforce no less (both have money to weather this storm but are on the meds). will all announce in the first quarter I predict,” tweeted investor Jason Calacanis.
Vance Ginn, president of a consulting firm and a senior fellow at Young Americans for Liberty, tweeted, “As layoffs surge, worker resilience faces a test in 2023 via @WSJ. I expect job losses to increase rapidly during #recession and will worsen in 2023 as recession deepens with increased #inflation and #interest rates.”
JP MORGAN’S JAMIE DIMON IS MORE OPTIMISTIC ABOUT US CONSUMERS
This image taken on July 4, 2022 shows the logo of Amazon, a major online shopping company, on display at the Amazon Amagasaki Fulfillment Center in Amagasaki, Hyogo Prefecture. ((Photo by KAZUHIRO NOGI/AFP via Getty Images) / Getty Images)
In October, Goldman Sachs CEO David Soloman said there was a “good chance” of a recession in 2023.
Fears of a recession have been brewing for months as the Federal Reserve hikes interest rates to combat high inflation and makes borrowing more difficult. The Federal Reserve’s actions are aimed at slowing down the economy in order to lower prices.
A sign is displayed at the Goldman Sachs reception in Sydney, Australia May 18, 2016. Portal/David Gray/File Photo (Portal Photos)
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In 2022, the US briefly slipped into a technical recession. With the stock market posting record losses over the past year and turbulence on board, many analysts are predicting the worst is yet to come.
Tesla has started releasing its quarterly Autopilot safety reports after pausing for a year. The automaker claims some improvements.
Since 2018, Tesla has attempted to establish a benchmark for its Autopilot safety improvement by releasing a quarterly report that compares the number of miles per accident with Autopilot versus without Autopilot.
Data has always been limited and has been criticized for not taking into account that accidents are more common on city roads and undivided roads than on motorways, where autopilot is most often used.
However, it was still helpful to compare it to itself over time and see if there were any improvements, and sometimes there were some incremental improvements.
Tesla suddenly stopped publishing these earnings reports in 2022 without any explanation.
Now the automaker has decided to ramp it up again, releasing reports for all quarters through Q3 2022.
Tesla wrote for the latest data:
In Q3, we recorded one accident per 6.26 million miles driven where drivers were using Autopilot technology. For drivers not using Autopilot technology, we recorded one accident per 2.71 million miles driven. In comparison, the latest available data from NHTSA and FHWA (as of 2021) shows that there was an automobile accident approximately every 652,000 miles in the United States.
That compares to one accident per 4.35 million miles driven with Autopilot technology in the fourth quarter of 2021 — the last time Tesla released the data regularly.
Tesla was also kind enough to plot the data on a chart this time for better visualization:
As you can see, it’s up and down, but that’s partly seasonal. In winter there are notoriously more accidents due to road conditions and because it gets dark earlier.
Since Tesla stopped collecting data, the automaker has also significantly expanded its Full Self-Driving Beta program, which actually allows for the use of more Autopilot technology on city streets.
However, it’s unclear whether Tesla is including this data in this report.
Electrek’s take
I know. It’s a very limited dataset and I also wish Tesla was more transparent, but it’s the best we have right now and it shows some improvement.
We have to work with that now.
As I reported recently, I really hope that Tesla will release more data specifically about its FSD beta program so we can start to see some solid numbers that pave a way for Tesla to deliver on its self-driving promise.
The company’s reboot to publish these reports could be a step in that direction. We will see.
FTC: We use income earning auto affiliate links. More.
A well-established French family in Quebec faces deportation in the face of federal bureaucracy as the Legault and Trudeau governments seek to attract more French-speaking immigrants.
• Also read: Good news in the country: The Quebec region welcomes few immigrants
• Also read: Canada welcomed a record number of new arrivals in 2022
• Also read: Immigration and language: Trudeau must walk the talk, says François Legault
Arriving two years ago, Aurélie Martin and Flavien Di Virgilio are desperate. The dream of this couple and their three children turns into a nightmare.
Immigration Canada just denied the extension of her open work permit.
They have 90 days to resolve their situation and attempt to obtain alternate status, otherwise they must leave Quebec soil.
But the processing times make the task practically impossible, especially since they no longer have a work permit and are therefore without an income.
“They want people who speak good French, who fit in, who spend their money here, so why make it so difficult for us? […] We’re just a number, we’re not treated like people,” complains the mother, who experienced this refusal as a “devastating blow”.
“Our bosses want to keep us”
Until last Friday, she was the manager of a grocery store in Greenfield Park while her husband worked at Héma-Québec.
Her three daughters, aged nine, eleven and thirteen, are well integrated into their community and do not want to return to France.
“Our bosses are trying to find solutions because both of our bosses want to keep us,” insists Ms. Martin.
She would have liked to hire an attorney to help her on her crusade to get another work permit from Immigration Canada, but she was forced to stop working abruptly last Friday when she received the unfavorable opinion. Now without a salary, the couple cannot afford it.
Aurélie Martin doesn’t understand Immigration Canada’s decision. However, she had rushed by submitting her application for an extension in August, four months before her work permit expired.
She followed the instructions on the federal government’s website to the letter. It is impossible to speak to a Ministry agent verbally.
“Agent M”
“You have not demonstrated that you are eligible to apply for an open work permit under immigration and refugee protection regulations. Your prospective employer is responsible for obtaining a valid Labor Market Impact Assessment (LMIA) and endorsement from Employment and Social Development Canada,” said the federal document, signed by “Officer M” of the Case Processing Center in Edmonton.
“If you do not wish to apply for reinstatement, you must leave Canada immediately or enforcement action may be taken against you,” the notice concludes.
But the processing times for LMIA applications make the success of the Martin-Di Virgilio family’s efforts all but unlikely.
“It doesn’t seem feasible at all to me, these are crazy delays, they’re asking three to six months for an LMIA, how do you expect it to be resolved in 90 days? And without working, because suddenly we have no income! »
Stuck in the wheels
Because the small family immigrated to Quebec in the middle of a pandemic, the couple was unable to start work as planned upon arrival.
They have therefore not yet fully accumulated the 24 months of employability that would qualify them for the Quebec Selection Certificate, a requirement for applying for permanent residency.
They are missing a few weeks that they cannot complete within 90 days because they had to stop their work immediately at the request of the federal government.
“It seems we get in each other’s way all the time. We pay our bills, we pay our taxes. We’re not billionaires, we’re Lambda, a normal couple, we don’t want free travel either, but we tell ourselves it’s not fair what’s happening to us, the mother regrets. We are an ordinary French family just waiting to work and live in Quebec! »
Excerpts from Immigration Canada’s decision
“Based on your application and the evidence you submitted, I have carefully checked all the information and have come to the conclusion that you do not meet the requirements of the protection of foreigners and refugees and its implementing regulations. Your application was rejected as submitted. »
“You have not demonstrated that you are eligible to apply for an open work permit under immigration and refugee protection regulations. Your prospective employer is responsible for obtaining a valid labor market assessment and endorsement from Employment and Social Development Canada. »
“You do not have temporary residency status in Canada. If you do not wish to seek reinstatement, you must leave Canada immediately or enforcement action may be taken against you. »
Heartfelt,
agent m
Edmonton case processing center
Letter from Aurélie Martin
The letter from Immigration Canada to Ms. Martin.
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Fox News Digital automotive editor Gary Gastelu resigns from ‘Varney & Co.’ at to discuss Rivian Automotive with the delivery of its electric SUV R1S.
Several top executives at Rivian Automotive Inc., including the vice president of body engineering oversight and head of supply chain, have left the EV startup in recent months as the company ends a year of falling short of its production targets .
The departures, which were confirmed by a Rivian spokeswoman, are the latest developments at a challenging time for Rivian, which launched its first all-electric models but missed a critical milestone of manufacturing 25,000 vehicles last year. The company said it was off target by about 700 vehicles, partly because of the difficulty in getting parts.
Rivian stock has also plummeted since its blockbuster IPO in November 2021, down around 79% by Tuesday’s close.
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The departing executives were some of Rivian’s longer-serving employees. Among them are Randy Frank, vice president of body and interior engineering, and Steve Gawronski, vice president of parts purchasing. Both had left earlier this year.
Mr. Frank joined Rivian in 2019 from Ford Motor Co. Mr. Gawronski joined in 2018 from the autonomous vehicle startup Zoox.
Another early employee, Patrick Hunt, a senior director on the strategy team, left the company late last year. Mr. Hunt joined Rivian in 2015.
Rivian’s General Counsel, Neil Sitron, left the company in September after 4½ years with the company, which was founded in 2009.
Rivian’s spokeswoman said the steps were taken to ensure the startup has the talent and people it needs to ramp up production. The company did not want to comment on the individual circumstances of the departures.
“We continue to attract world-class talent to our company as our business needs change,” she said.
AMAZON’S RIVIAN ELECTRIC VANS NOW DELIVERY TO 100 CITIES
Large crowds came to view Rivian Automotive’s R1S prototype during a public launch of the company’s new vehicles in Normal, Illinois on October 13, 2019. (David Proeber/The Pantagraph via AP/AP Newsroom)
The departures mark the recent reshuffle at the helm of Rivian, which has brought new executives to oversee the company’s manufacturing operations. The company’s first full year of factory production was marred by supply chain issues and difficulties in getting the assembly line up to speed.
Tim Fallon, former Nissan Motor Co. factory manager in Canton, Miss., was hired in early 2022 to run Rivian’s only factory in Normal, Illinois.
In June, Rivian hired Frank Klein as chief operating officer of contract manufacturer Magna Steyr.
In a November email to employees reviewed by the Journal, Mr. Klein wrote that with Mr. Gawronski’s departure, the company took the opportunity to make some organizational changes to ensure it can handle the increasing complexity, that the group will face in the years to come.
Mr. Klein added that Rivian was reorganizing its supply chain management, making one vice president responsible for supply chain and logistics and another for parts sourcing.
He also announced that Rivian has hired Andreas Reutter of toolmaker Stanley Black & Decker Inc. to oversee Rivian’s supply chain logistics.
RIVIAN ANNOUNCES MAJOR VEHICLE RECALL
RJ Scaringe, founder and chief executive officer of Rivian Automotive Inc., unveils the R1T electric pickup (left) and R1S electric sports utility vehicle (SUV) during an unveiling event at AutoMobility LA ahead of the Los Angeles Auto Show in Los ( (Patrick T. Fallon/Bloomberg/Getty Images)
The changes at the top of Rivian come as the company seeks to transform itself from an upstart looking to raise capital to a mass manufacturer with ambitions to become one of the largest automakers in the world.
Its first all-electric models, the R1T pickup and R1S SUV, are relatively new. The company has only been building cars at its Illinois plant since late 2021. Until then, it had never built or sold a single retail vehicle.
As part of its expansion, Rivian embarked on a hiring spree, rapidly growing from about 1,200 employees in 2019 to about 14,000 employees last summer, and has only recently begun to create positions that exist in many companies.
In April, jewelry maker Tiffany Inc. hired Anisa Kamadoli Costa as chief sustainability officer. In October, Rivian hired a former Capital One Financial Corp. executive, Diane Lye, as its first chief information officer.
ELECTRIC CAR COMPANY REVEALS WHY PEOPLE ARE REALLY BUYING ELECTRIC CARS
Workers lower an R1T truck body onto a chassis on the assembly line at the Rivian electric vehicle plant April 11, 2022 in Normal, Illinois. (Brian Cassella/Chicago Tribune/Tribune News Service via Getty Images) (Brian Cassella/Chicago Tribune/Tribune News Service via Getty Images/Getty Images)
As Rivian struggled to increase factory production, it came under pressure to cut spending. Last summer, the company laid off about 6% of its workforce and cut spending on many of its programs.
The company focused on ramping up production of its current set of vehicles. It also makes an electric delivery truck, which it sells to Amazon.com Inc.
One example of the young automaker’s shifting priorities is that Rivian has suspended negotiations with Mercedes-Benz AG over a proposed van partnership in Europe, which had been an expansion target for Chief Executive RJ Scaringe. Rivian said the decision came after a reassessment of growth opportunities.
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The company reported a net loss of $5 billion for the first nine months of 2022 and its cash position fell to $13.8 billion at the end of September, compared to $15.46 billion in June. Rivian is expected to release its annual results on February 28th.
Fake millionaire Serge Rivard is said to have tricked at least seven women via dating site Badoo, including one who ended up on the street after crossing his path.
• Also read: Fake millionaire still accused of cheating on women he allegedly seduced
“I’m scarred by it for life. I lost everything, I found myself on the street because of him! I’m still suffering from it,” said Caroline Cloutier, who lost her money and home after meeting Serge Rivard, whom she knew as Charles Danny Quintal.
Our investigative agency revealed yesterday that Serge Rivard, who presented himself under several false names, extorted thousands of dollars from women he had promised money, travel, houses and a life of luxury.
It is thanks to our report that Ms Cloutier learned yesterday for the first time the real names of those she visited from August to November 2021.
“When I saw that, I started to cry […] I’ve been through hell,” breathes the Laval resident.
“He took money from one of my friends, from my parents, he lived under my arm,” adds the mother of the family.
rich heritage
As he would have done with several other women, Serge Rivard would have presented himself as a rich heir. He said he owned companies, a mansion in Germany, art galleries and shops.
But the slick talker never had access to his accounts.
“The money was frozen, the lawyers took care of it, he wanted to give us the money back and he promised us millions because we would lend him money,” the lady recalls.
At one point, Ms. Cloutier, who was behind on her rent, was evicted from her apartment.
With Serge Rivard she would have found refuge in the hotel and with a relative. A friend of her daughter discovered the rose pot while researching on the internet.
“I had just realized that I had just been attacked,” laments Ms. Cloutier, who eventually found refuge in a women’s shelter.
Seven cheated women
Our Bureau of Investigation has listed at least seven women who believe they were cheated and fell in love with Serge Rivard after meeting him on Badoo.
Terrebonne-based Daniela Leoni had to travel to all corners of the world with Serge Rivard, who presented himself under the name Danny Gauthier. But he would rather have stolen thousands of dollars from her by cashing fake checks.
Eastman’s Nathalie Grimard would have been fooled by Serge Rivard, renamed Danny Ménard, in the fall of 2018. She would have discovered the web of lies after three months of dating and after she and her relatives had lost thousands of dollars.
Real doctor’s photo used
Fraudster Serge Rivard, who presented himself under several false names including Danny Gauthier, is said to have used a photo of a Montreal doctor to illustrate his profile on dating site Badoo a few years ago.
Informed by an acquaintance that his picture was circulating on this social network, the “real” Danny Gauthier reported it to the police.
“I was wondering if he came to the clinic to see me before taking the picture because the description of my body on Badoo was very accurate,” says Dr. Gauthier.
Serge Rivard would also have used the image of an athletic young man to communicate with Daniela Leoni, from whom he extorted thousands of dollars last fall.
“He told me he didn’t look like the picture, he didn’t have a beard anymore, he didn’t dye his hair anymore and he’d put on a bit of fat,” recalls the woman from Terrebonne.
Serge Rivard, 58, has a criminal record for fraud and is facing new fraud allegations. Arrested before Christmas, he has to undergo his release examination this morning.
