According to the official Wafa news agency, the plane attacked two houses in Deir al-Balah, claiming 15 lives who were later taken to Al-Aqsa Martyrs Hospital.
Civil defense teams were still searching for people buried under the rubble, he emphasized.
The news agency reported that two other civilians died in a similar incident in Jabalia refugee camp.
Around 70 refugees were accommodated in the house that was attacked, so the actual number could be significantly higher, he warned.
After the bombings in the districts of Al-Zaytoun, Tal Al-Hawa, Al-Sabra and Al-Daraj, another ten deaths and numerous injuries were recorded in the northern city of Gaza.
Israeli artillery strikes left three people dead and seven injured in the nearby town of Beit Hanoun.
Wafa reported that two others lost their lives in the southern city of Khan Yunis and two others in Rafah.
According to official figures, more than 30,220 Palestinians have died and another 71,300 have been injured since Israel's aggression against the coastal enclave began on October 7.
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