San Diego has hosted the Holiday Bowl since 1978, and the Pac-12 has attended since 1997. However, as we know, the 2023 Holiday Bowl will be the last time a Pac-12 program will compete in the conference for the foreseeable future as it ends after this season. The No. 15 Louisville Cardinals (10-3) are coming off an ACC Championship Game loss to Florida State and will face the USC Trojans (7-5) on Wednesday.
Kickoff is scheduled for 8:00 p.m. ET at Petco Park in San Diego, California. The latest Louisville vs. USC odds have the Cardinals as 7-point favorites and the over/under is at 59 points, according to the SportsLine consensus. Before entering USC vs. Louisville picks for the 2023 Holiday Bowl, be sure to check out the college football predictions from the model at SportsLine.
The SportsLine projection model simulates every FBS college football game 10,000 times. Since its inception, it has generated a strong profit of well over $2,000 for $100 players with its top-rated college football picks against the spread. It started the bowl season with a profitable record of 13-9 on top-rated spread picks. Everyone who has pursued it has achieved tremendous success.
The model has Louisville vs. USC in its sights. You can head over to SportsLine to check out the picks. Here are several college football betting lines for the USC vs. Louisville game:
- Spread between Louisville and USC: Louisville -7
- Louisville vs. USC over/under: 59 points
- Moneyline Louisville vs. USC: Louisville -272, USC +221
- Louisville vs. USC Picks: Check out the picks here
- Louisville vs. USC live stream: fubo (try for free)
Why Louisville Can Cover
Both teams will be affected by high-profile opt-outs, but Louisville will have quarterback Jack Plummer in action. The former Purdue and Cal starter threw for 3,063 yards and 21 touchdowns with 12 interceptions in his only season at Louisville.
More importantly, Louisville's defense hasn't been significantly impacted by the transfer portal or opt-outs, having allowed just 19.7 points and 307.4 yards per game this season. Ashton Gillotte announced he will return to Louisville next season after an 11-sack season, and Devin Neal will also be in action after recording 67 tackles and intercepting four passes. See which team you should choose here.
Why USC can cover
USC started the season ranked No. 6 in the country and posted six straight wins, but ended the season losing five of six. Now the Trojans are without quarterback Caleb Williams, running back MarShawn Lloyd and wide receiver Brenden Rice due to opt-outs. Several other key contributors have entered the transfer portal, but Riley must view this as an opportunity to hit the reset button after a disappointing season.
Miller Moss now has the opportunity to lead the team as the starting quarterback, and his numbers are impressive in an admittedly small sample. He has completed 72.9% of his passes and averaged 9.2 yards per attempt with three touchdowns and no interceptions over 59 career attempts as a backup. He also scored a couple of touchdowns and Moss will be looking for a big game to cement his status as a starter in 2024. See which team you should choose here.
How to pick Louisville vs. USC
The model has simulated Louisville vs. USC 10,000 times and the results are in. The model leans forward and has also generated a point spread pick that hits in almost 60% of simulations. You can only see the pick at SportsLine.
So who wins USC vs. Louisville and which side of the spread scores nearly 60% of the time? Visit SportsLine now to see which side of the 2023 Holiday Bowl spread you should jump on, everything from the advanced computer model that has earned well over $2,000 since its inception compared to its top-rated college football spreads. Picks has risen and find out.