Another week of NFL action is here, which means there are certainly more surprises in store. After all, in the first five weeks, we’ve already seen the Cowboys fall victim to a 49ers loss, the Jets beat Sean Payton’s Broncos, and CJ Stroud easily outpace this year’s rookie quarterbacks in Houston. How then can you be sure you are betting on the right players and teams in Week 6?
Like every week, we’ve collected the best picks and gambling content from CBSSports.com and SportsLine and put them in one place so you can get tips against the spreads from our CBS Sports experts as well as additional feature content for every game, including plays from the best SportsLine experts and the SportsLine Projection Model, our staff’s best bets, survival tips and more. Ready? Let’s get in.
All NFL odds via Caesars Sportsbook.
What picks can you make with confidence in Week 6? And which Super Bowl contender will be eliminated? Visit SportsLine, whose incredible model simulates every NFL game 10,000 times and costs nearly $7,000 more for $100 players on top-rated NFL picks.
Commanders at Falcons
Time: Sunday, 1:00 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Falcons -2.5, O/U 42
Recommended Game | Atlanta Falcons vs. Washington Commanders
SportsLine’s NFL projection model, which simulates every NFL game 10,000 times, has risen well over $7,000 on top-rated NFL picks since its inception for $100 players. The model enters Week 6 of the 2023 NFL season with a 171-119 run on top-rated NFL picks dating back to the 2017 season. And there is a strong game this weekend as the Falcons (-2.5) cover in nearly 60% of simulations against the Commanders. For more analysis of the model, visit SportsLine here.
Vikings with bears
Time: Sunday, 1:00 p.m. ET (FOX), stream on fubo (try for free)
Open: Vikings -3.5, O/U 49.5
Recommended Game | Chicago Bears vs. Minnesota Vikings
The Vikings remained tied with the reigning champion Chiefs in Week 5, but now they face their first NFC North opponent of the season and will be without star receiver Justin Jefferson. The Bears weren’t world-beaters, of course, but they did come off an extra break and got a big win over the Commanders, with Justin Fields finally finding his footing in the air. Is it safe to put Minnesota as the away favorite? Or is something actually brewing in the Windy City? Check out SportsLine for current ATS predictions, including for this divisional showdown between two 1-4 teams.
Seahawks at Bengals
Time: Sunday, 1:00 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Bengals -2.5, O/U 43.5
Recommended Game | Cincinnati Bengals vs. Seattle Seahawks
“For the Bengals, Joe Burrow is finally starting to look like Joe Burrow, which is good news for him but bad news for the Seahawks. After rushing for 317 yards and three touchdowns against the Cardinals, Burrow is now facing a Seahawks defense.” That means he’s giving up 280 passing yards per game, which is the third-worst number in the NFL. Burrow could throw for 500 yards. … The Seahawks will also go into this game without a bye, which is usually an advantage for most teams, but not them. The Seahawks are 0-3 after their bye since 2020, so I say the curse of bye week continues for Seattle.”
Resident Bengals expert John Breech has plenty of reasons to support Cincy here. Find all of his tips for Week 6 here.
49ers at Browns
Time: Sunday, 1:00 p.m. ET (FOX), stream on fubo (try for free)
Open: 49ers -3, O/U 41.5
Recommended Game | Cleveland Browns vs. San Francisco 49ers
SportsLine’s simulation model has ranked in the top 10 in straight NFL picks on NFLPickWatch in four of the last six years, beating more than 94% of CBS Sports’ football pick’em players four times during that period. Smart bets are now forecast for a five-team game that could result in a payout of 25-1. We can reveal part of the game plan: The model says the 49ers (-7) will cover on the road against the Browns in nearly 60% of simulations, making it one of the model’s strongest NFL picks for Week 6. For more information on the parlay and analysis of other ATS picks, visit SportsLine here.
Panthers and dolphins
Time: Sunday, 1:00 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Dolphins -10.5, O/U 46
Recommended Game | Miami Dolphins vs. Carolina Panthers
“With some rare exceptions, home and away splits don’t seem to matter as much these days, with away teams starting the week 41-37. The expanded international schedule continues to produce similar results and there are some trends that we are following as our friend until proven otherwise.” Could this have an impact on SportsLine NFL expert Jason La Canfora’s forecast for this one game, or are the Dolphins immune given their explosive lead against an 0-5 Carolina team? Be sure to check out JLC’s full breakdown on this topic, as well as other best bets for Week 6, here.
Colts at Jaguars
Time: Sunday, 1:00 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Jaguars -4.5, O/U 45.5
Recommended Game | Jacksonville Jaguars vs. Indianapolis Colts
“We have Gardner Minshew’s vendetta in the game. And honestly, I just think that line should be three. Jacksonville is coming off a stint in London – they’ve been in London for two weeks – and I could see that offense. “Be a little lethargic. … That to me is a good spot for the Colts to keep it within a field goal. Josh Downs looks good here too.
That’s CBS Sports senior writer Will Brinson highlighting both ATS and potential prop bets he likes in the AFC South tournament. His full game recap and other Week 6 bets can be found here on the Pick Six NFL Podcast.
Saints among Texans
Time: Sunday, 1:00 p.m. ET (FOX), stream on fubo (try for free)
Open: Saints -1.5, O/U 40.5
Recommended Game | Houston Texans vs. New Orleans Saints
CBS Sports Fantasy and Gaming Editor RJ White has twice won big money at the world’s most prestigious handicapping tournament, the Westgate Las Vegas SuperContest. His Vegas content selection is 376-290-24 (56.5 percent). And he shares these five weekly tips on SportsLine. We can tell you he’s picking Houston, which got off to a hot start from rookie quarterback CJ Stroud in Week 6, but you’ll want to head over to SportsLine for a full breakdown of his picks.
Patriots at Raiders
Time: Sunday, 4:05 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Raiders -1.5, O/U 42.5
Recommended Game | Las Vegas Raiders vs. New England Patriots
“People continue to wait for the Patriots to show a spark of life, and that has yet to come. And if you think it’s going to be in Las Vegas this week, I think you’re going to be left out in the cold once again. New England is averaging just 11 points per game this season and a big reason for that is their inability to guard Mac Jones. While the quarterback has made some terrible decisions himself, he has also been pressured on 21.9% of his dropbacks (career high). Do we think Maxx Crosby and his 34 pressures (second most in the NFL) will help or hurt that percentage? For a Patriots team that has gone 1-8 ATS in its last nine games, this is likely another chapter in what has been a steep fall from grace.
Not even resident Patriots expert Tyler Sullivan is willing to push New England here. Find all of his ATS picks for Week 6 here.
Cardinals at Rams
Time: Sunday, 4:25 p.m. ET (FOX), stream on fubo (try for free)
Open: Rams -4.5, O/U 46
Recommended Game | Los Angeles Rams vs. Arizona Cardinals
“This is a good spot for Matthew Stafford, Cooper Kupp and Puka Nacua after a tough loss to the Philadelphia Eagles. The Cardinals are 1-8 in their last nine games against the NFC West and just lost James Conner to injured reserve. By the way, did you notice that Stafford throws the rock in the air? He has three games with more than 300 passing yards, which ranks first in the NFL. The Cardinals have lost their last five road games and are outnumbered by about 12 points per game in those contests. The Cards started strong this year by covering the spread in each of their first three games. However, they haven’t reached that number for two weeks and are suffering their worst defeat of the season at home.”
Jordan Dajani of CBS Sports considers the Rams to be the home favorite in this divisional duel. Find all of his tips for Week 6 here.
Eagles at Jets
Time: Sunday, 4:25 p.m. ET (FOX), stream on fubo (try for free)
Open: Eagles -6.5, O/U 42.5
Recommended Game | New York Jets vs. Philadelphia Eagles
“That line has unfortunately crossed a pretty obvious key number, but I’m not sure that really matters. The Eagles’ second half against the Rams was incredibly impressive from a defensive standpoint. If Philly plays like that against the Jets.” Zach Wilson has no chance on Sunday. New York’s defense is very good, but it is also a unit that must stop a very effective running game with multiple defenders and a passing attack that includes a trio of top-notch weapons in AJ Brown, DeVonta Smith and Dallas Goedert. The short version is that I think the Eagles overwhelm the Jets and win by more than a touchdown pretty easily. A second half where Wilson has to throw the ball around (New York won’t be able to run here). ) will not lead to a comeback.”
CBS Sports senior writer Will Brinson sees the Birds as one of his best bets heading into Week 6. Check out all of his picks here.
Lions at Buccaneers
Time: Sunday, 4:25 p.m. ET (FOX), stream on fubo (try for free)
Open: Lions -3, O/U 45.5
Recommended Game | Tampa Bay Buccaneers vs. Detroit Lions
“This is a huge game for both teams. The Lions are 4-1 after dominating the Panthers last week, while the 3-1 Bucs have a bye. Baker Mayfield is playing well, but the Lions defense is strong. That’s how it’s going to be.” We’ll be close, but the Bucs will find a way to win late as Mayfield gives them a late-game field goal to win.
That’s CBS Sports senior columnist Pete Prisco riding a surprise in Tampa Bay. Find all of his predictions for Week 6 here.
Giants at Bills
Time: Sunday, 8:20 p.m. ET (NBC), stream on fubo (try for free)
Open: Bills -12.5, O/U 48
Recommended Game | Buffalo Bills vs. New York Giants
CBS Sports fantasy and gambling editor RJ White, who has had tremendous success with ATS picks, also has a real feel for the Giants, going 42-22 (+1674) in his last 64 picks with New York prior to Week 5. Who knows that? Does he like it here? For his complete ATS picks and analysis, head over to SportsLine here.
Cowboys at Chargers
Time: Monday, 8:15 p.m. ET (ESPN, ABC), stream on fubo (try for free)
Open: Cowboys -2.5, O/U 47.5
Recommended Game | Los Angeles Chargers vs. Dallas Cowboys
SportsLine expert Larry Hartstein combines an extensive network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He finished 52nd (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest with a 53-34-3 ATS record. That pick formed the basis of his SportsLine NFL best bets article, which finished 36-25-1. Now he’s back with a primetime projection. We can tell you he’s on the edge here in the overall standings, but you’ll have to head over to SportsLine to see his full ATS picks and more Week 6 analysis.